Melanom in situ – korrekt diagnose og prognose

Anne E. Cust, PhD, MPH(Hons)^1,2,3; Richard A. Scolyer, MD, BMedSci, MBBS^2,4,5,6Forfatteraftalelser Artikel InformationJAMA Dermatol. Published online June 7, 2023. doi:10.1001/jamadermatol.2023.1485

I dette nummer af JAMA Dermatologi, Patel and colleagues¹ examine mortality after a diagnosis of melanoma in situ. Melanoma in situ is the earliest stage of melanoma (stage 0) and is localized to the outermost layer of skin (epidermis). It is regarded as a potential precursor lesion to invasive melanoma (stages I to IV), in which melanoma invades the deeper layers of the skin and, in doing so, acquires the potential ability to spread to distant sites, which may ultimately lead to death from melanoma. Nevertheless, melanoma in situ is not an obligate precursor of invasive melanoma, and it is increasingly acknowledged that some lesions diagnosed as melanoma are clinically indolent and will never progress.² The latter scenario is often referred to as overdiagnosis of melanoma.³

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